Job Description

Join our dynamic team at SOPHiA GENETICS, a leading innovator in the field of data-driven precision medicine, as an Algorithm Developer Intern. Over 30% of staff at SOPHiA GENETICS hold PhDs. You will be joining a small team of experts specializing in the research and development of cutting-edge software solutions for accurate detection of large structural variants from Next Generation Sequencing (NGS) data.

Your mission:

Gene fusions are the driver mutations in 10% to 20% of cancer cases. Correctly identifying such fusions often has substantial therapeutic implications. SOPHiA GENETICS has developed leading algorithms for detection of gene fusions from DNA (hybrid capture or whole genome) and RNA sequence data, for a variety of clinical applications. This internship will contribute to this effort. By joining us, you'll have the opportunity to contribute to the research and development of state-of-the-art tools at the cutting edge of the field, with impact on research and clinical applications worldwide.

You will be involved in:

NGS data exploration to gain initial insights, for example through testing the analytical performance of existing algorithms. Technical analysis, e.g. through statistical models, to evaluate the limits of analytical performance and how it may be improved. Evaluation of the technical feasibility, e.g. by developing prototype algorithms, of such improvements. Critical evaluation and management of the day-to-day running of the project, including documenting the performed activities Presentation of results to members of the team/department/senior management.

What will you learn:

How to work with real-world NGS data, including BAM files and structural variant analyses Familiarization with products and analyses used in clinical genetics DNA and RNA panels somatic and germline applications Data exploration, statistical analyses, and visualization techniques Software development: Contribute to software development with industry-level standards How to contribute to scientific innovation within a matrix organization Best practices for communicating complex results to technical and non-technical audiences

Requirements

The experience you bring:

PhD in a quantitative discipline (Statistics, Mathematics, Physics, Computational Biology, Data Science). Exceptional applicants with, or pursuing, a Masters degree will also be considered. Excellent analytical and algorithmic skills, with strong appreciation for statistics and probability Some experience in manipulating NGS data (bam files) Knowledge of programming, ideally in R and/or C++ Proficiency in English (spoken and written) Independence and experience in driving research projects Good teamwork and collaboration skills Good communication and presentation skills

Benefits

You will be joining an organisation with the patient at the heart of every decision and action, driven by purpose as we pursue exponential growth.


Business recognition and accolades include:

World's most innovative companies (Top 10) World's smartest companies (Top 50) 100 Best Places to Work in Boston Top 10 European Tech Startup Top 10 European biotechs startup to watch Top 25 East-Coast Biotech to watch

Our benefits package is comprehensive, but varies internationally in-line with local standards and laws. You can discuss a full breakdown with us, but as a brief overview:

Sickness and Accident coverage through Helsana Meal Vouchers at 90CHF PM with our partner cafeteria A fun and engaging work environment, with Rest & Entertainment space, full stocked free coffee machine and free fruit/snacks Free parking in an easy to access location A strong social committee whose purpose is to make SOPHiA GENETICs both enjoyable as well as rewarding As our global HQ, you'll have direct interaction and exposure to senior leadership and our executive team locally

Our DNA

Like the strands of DNA itself, SOPHiA GENETICS and the team are deeply interconnected and reliant on each other to deliver. There are common threads across the team. Things that bind us together. Those things are Relentless Curious; Resilient & Nimble and Fearlessly Adventurous

Our Virtues

At SOPHiA GENETICS we established our 7 Virtues to clarify how our principles show up each day through action. We Decide; We Do; We Collaborate; We Innovate; We Empower; We Adapt and We Learn.


At the centre of our Virtues is our Mantra, We Care, which provides a constant reminder of the compassionate, benevolent, and hopeful nature of our mission and how it should be threaded through each of our Virtues and everything we do. Learn more about our DNA and Virtues on our Careers portal

The Process

We use the power of AI to help our partners make decisions. If you're utilising AI in your search and application process, why not use some of these prompts:



'What impact can I expect to have on the world by working at SOPHiA GENETICS?'


'I have an interview with SOPHiA GENETICS. What should I know before I meet with them?'


'I am a job title - What can SOPHiA GENETICS offer my career?'



Apply now with your CV and any supporting information.


Suitably qualified candidates will be invited through an interview and screening process where you will speak with members of our Talent Acquisition Team, the hiring leader alongside key colleagues and stakeholders from across the business. If you need additional support for accessibility, please contact our TA team for assistance.


We appreciate the value external partners can bring, but we operate a direct-hiring model and we are not looking to utilise agency support at this time. All hiring is controlled by Talent Acquisition, potential partners should liaise through TA and not our hiring teams please.





Starting Date: February 2026


Location: Rolle, CH


Contract: Internship, full time - 6 months