Job Description

Your tasks

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Conduct a PhD project on enzyme reaction mechanisms using time-resolved serial crystallography at synchrotron and XFEL facilities Prepare and run temperature-controlled experiments (e.g., T-jump) to probe transient intermediate states Analyze and interpret high-resolution crystallographic datasets to extract mechanistic insight into enzymatic processes Apply - and where needed, help advance - biophysical methods supporting protein structure/function analysis Optimize experimental sample preparation, including protein expression and purification

Your profile

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Master's degree or equivalent in Chemistry, Biochemistry, Molecular Biophysics, or a related field Hands-on experience with biophysical techniques (e.g., CD, fluorescence spectroscopy, ITC) and protein purification (e.g., FPLC) Strong analytical skills, initiative, and the ability to thrive in a multidisciplinary team Prior experience in crystallography (macromolecular crystallography, serial crystallography, crystallographic data processing/refinement) is highly valued

We offer

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Our institution is based on an interdisciplinary, innovative and dynamic collaboration. You will profit from a systematic training on the job, in addition to personal development possibilities and our pronounced vocational training culture. If you wish to optimally combine work and family life or other personal interests, we are able to support you with our modern employment conditions and the on-site infrastructure.

For further information, please contact Dr Tobias Weinert, phone +41 56 310 54 55.

Please submit your application online by

31 January 2026

(including addresses of referees) for the position as a PhD Student (Index-Nr. 2316-23974).

Paul Scherrer Institute, Human Resources Management, Pascale Bartschi, 5232 Villigen PSI, Switzerland