Job Description

The Department of Biomedicine (DBM) integrates basic and clinical researchers from University of Basel and University Hospitals committed to deepen the understanding of health and disease while driving the development of innovative therapies that address unmet medical needs. With over 70 research groups and 800 employees, the Department of Biomedicine is the largest department within the University of Basel. Be part of our future!




The Wymann lab at the DBM Mattenstrasse, University of Basel, Switzerland, invites qualified candidates to apply for a post-doctoral position in Medicinal Chemistry. The candidate will join a multi-disciplinary team focusing on the development of new bioactive molecules targeting major signaling pathways in allergy, inflammation and cancer. Main targets are stress kinases vital for immune reactions, metabolic control and immune checkpoint modulation in cancer therapy.



The working place of the successful candidate is the Department of Biomedicine at Mattenstrasse 28, 4057 Basel.

Project:

Main focus: Targeting cell surface receptor signaling by newly designed covalent, PPI and allosteric inhibitors within an Innosuisse-funded project aiming to open a path to lead compounds for therapeutic applications.

For technically relevant recent publications see Borsari et al. (2022) J. Am. Chem. Soc. 144: 6326-6342; Bissegger et al. (2024) Chem. Sci., 15:20274-20291



This project is flanked by basic reasearch projects

i) developing novel chemical probes and degraders to dissect mechanisms of adverse effects in cancer and metabolism. For a summary see: https://p3.snf.ch/project-204602.

ii) investigating of the role of phosphoinositide 3-kinase (PI3K) signaling in allergy, metabolic control, obesity, diabetes and cancer; see https://data.snf.ch/grants/grant/189065

Your position

Design, development and implementation of multi-step synthesis to access small heterocyclic molecules. Improve biological activity of hit compounds through structure-activity relationship (SAR) studies. Work in a multi-disciplinary environment (collaboration with biologists, organic chemists and computational chemists). Writing of scientific publications, patents and regulatory reports.

Your profile

The successful candidate holds a PhD in organic chemistry. Expertise in organic synthesis with emphasis on the synthesis of biologically active molecules is desired. The candidate has an excellent proven track record in the publication of peer-reviewed scientific articles and/or patents.

We offer you

University of Basel is an equal opportunity employer. Salaries are according to the staff-regulations and depend on the qualifications and experience of the candidate.

The position will be initially for one year with a possibility of extension based on performance.

Application

Please submit your resume (CV), a letter of motivation, a putative career plan, diplomas, and addresses of 2-3 references to the UniBas jobs portal at https://jobs.unibas.ch/?lang=en (if you are on it, see button below). Application via the https://jobs.unibas.ch/?lang=en platform is mandatory, applications by Email will not be considered. When on the portal enter the search terms "wymann lab" or "hypersensitivity".
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