Job Description

Contexte

------------


The Lausanne University Hospital (CHUV) is one of five Swiss university hospitals. Through its collaboration with the Faculty of Biology and Medicine of the University of Lausanne and the EPFL, CHUV plays a leading role in the areas of medical care, medical research and training.


The Department of oncology UNIL-CHUV brings together clinical and cancer research in a strong spirit of innovation. It comprises the services of medical oncology, immuno-oncology including advanced cellular therapies, radiation oncology, hematology including stem cell transplantation and the center for experimental therapies. It also integrates the Lausanne branch of the Ludwig Institute for Cancer Research (LICR), particularly in the field of immunotherapy.
We are seeking a highly motivated postdoctoral candidate to join our cancerimmunology group. The Rufer lab focuses on investigating human CD8 T-cell responses to self-(tumor) and foreign (viral) antigens, aiming to advance our knowledge of T cell-mediated protection from human disease and to develop strategies for adoptive cell therapies using engineered or natural anti-cancer T cells. We showed that the T cell receptor (TCR)-binding avidity is a valuable indicator for evaluating antigen-specific T cell responses, serving as a potential biomarker of T cell therapeutic effectiveness (1, 2) and a key parameter in regulating T-cell clonal repertoires during latent herpes virus infection (3).



Duong MN et al. Chronic TCR-MHC (self)-interactions limit the functional potential of TCR affinityincreased CD8 T lymphocytes. J Immunother Cancer. 2019; doi: 10.1186/s40425-019-0773-z

Carretero-Iglesia L et al. High peptide dose vaccination promotes the early selection of tumor antigenspecific CD8 T-cells of enhanced functional competence. Front Immunol. 2019; https://doi.org/10.3389/fimmu.2019.03016

Coutureaud B et al. Overall avidity declines in TCR repertoires during latent CMV but EBV infection. Front Immunol. 2023; https://doi.org/10.3389/fimmu.2023.1293090.

Mission

-----------


A postdoctoral position is now available to study the key biophysical and functional determinants of anti-tumor TCRs related to clinical efficacy using high-throughput screening technologies. The objectives are to determine the characteristics that define the most suitable and safe TCR candidates for adoptive T cell therapy.

Profil

----------


Candidates should hold a PhD or an MD/PhD in immunology, cancer biology or biochemistry, with a strong background in human T-cell biology. They must have solid theoretical and practical expertise in immunology or oncology, including cellular & molecular biology. Fluency in spoken and written English is prerequisite.

Nous offrons

----------------

To become an employee of the world-famous University Hospital Center from the Canton of Vaud is an assurance of:

First-rate social benefits such as a Paternity Leave of 20 days and a Maternity Leave of 4 months (there is also the possibility to obtain a complementary breastfeeding leave of 1 month) Regular salary progression adapted to your responsibilities A 13th salary and 25 days of vacations per year A right to at least three days of training per year, by accessing a wide offer of courses not only from the CHUV Training Center but also from external providers Possibility to access one of the 500 furnished apartments offered in the surrounding neighborhoods in case of relocation in Switzerland Discounts proposed on social and cultural events, goodies and other services, thanks to the "H-Oxygene" association Signing up to our Mobility Plan and benefit from different advantages (discounts on public transportation, promotion of "Mobility" car fleet and discounts on electric bikes) Being able to enjoy our high-quality corporate restaurants, located in every hospital building, with employees' discount.

Contact et envoi de candidature

-----------------------------------


Contact pour informations sur la fonction : Applicants should send a cover letter, including a brief statement of research experience and interests (max 2 pages), their curriculum vitae and publication list, as well as the names and contact information of three references.


Please send your application to: Dr. Nathalie Rufer, e-mail: Nathalie.Rufer@unil.ch.

Dans la mesure ou toutes nos candidatures sont traitees de maniere electronique, nous vous remercions de postuler exclusivement par internet, en cliquant sur le bouton POSTULER en bas de l'annonce.

En cas de difficulte pour postuler, vous pouvez consulter notre procedure comment postuler en ligne.

Si pour des raisons techniques vous ne parvenez pas a postuler en ligne

, nous vous invitons a contacter notre Unite recrutement, qui vous accompagnera dans votre demarche, soit par mail a e.recrutement@chuv.ch, soit par telephone au 021 314 85 70


Le CHUV applique les exigences de qualite les plus elevees dans le cadre de ses processus de recrutement. En outre, soucieux de promouvoir la diversite de nos collaboratrices et collaborateurs, nous sommes attentifs aux differents parcours de vie et mettons tout en oeuvre pour garantir l'egalite de traitement et eviter toute discrimination. Nous nous rejouissons de recevoir votre candidature.


Nous remercions par avance les agences de placement de prendre bonne note que les candidatures inserees par leurs soins directement sur notre plateforme de recrutement ne sont pas acceptees et ne peuvent donner lieu a une facturation. Merci de votre comprehension.