Job Description

Department of Molecular Mechanisms of Disease

Postdoctoral position: research on ADP-ribosylation-mediated regulation of cancer 100 %

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Start of employment October 1, 2025, temporary
A postdoctoral position in research on ADP-ribosylation-mediated regulation of cancer is available immediately in the group of Prof. M.O. Hottiger at the Department of Molecular Mechanisms of Disease.



The Department of Molecular Mechanisms of Disease offers a stimulating research environment, consisting of a multi-disciplinary team with different expertise and actively promotes dynamic interactions between scientists.



The workplace is situated within the natural sciences campus and the hospital of the University of Zurich, the largest University in Switzerland and one of Europe's leading research centers. The departments are equipped with state-of-the-art infrastructure for biochemical, molecular, and cell biological investigations.

Your responsibilities

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The project is funded by an Innosuisse grant and focuses on screening and validating small molecules that inhibit mono-ADP-ribosylation of proteins. The successful candidate will be expected to engineer cell lines, to optimize and conduct cell-based experiments, to validate and characterize a limited set predicted small molecule inhibitors, to statistically analyze data and to contribute to decision making in lead compound selection.

Your profile

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We are seeking a highly-motivated individual with a solid background in cell- and molecular biology (PhD in Molecular or Systems Biology), who is ideally familiar with the genetic complementation of cells. Programming skills (e.g. Python, R, Java, C, C++) and advanced experience with statistics/analytics are an advantage.



The applicant should be an independent thinker and problem-solver who is willing to work in a team, have a strong publication record, and accept new challenges arising from working in a high-paced scientific environment. The applicant should also have good communication and entrepreneurial skills, a curiosity-driven attitude, and demonstrate enthusiasm and flexibility.

Information on your application

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Please forward your application electronically (preferably as a single PDF file) with a detailed CV, a list of publications, a one-page summary of the scientific achievements, a statement of motivation, and the names and addresses of two references (informal and confidential inquiries should also be sent to this address).



The position is funded for 1.5 years (100 % with a salary according to the University guidelines). The workplace is at the Irchel campus of the University of Zurich (Winterthurerstrasse 190, 8057 Zurich). There is no formal application deadline, as the position will be filled as soon as a suitable candidate has been identified. The evaluation of applications will start immediately. Job sharing is not possible. Candidates should be able to start latest on October 1st, 2025.

What we offer

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Work-Life Balance

Flexible working models (such as part-time positions, mobile working, job-sharing) Childcare at the kihz foundation of UZH and ETH

Learning and Development

Wide range of continuing education courses of UZH and the Canton of Zurich Language Center run jointly with ETH Zurich

Food

Food and drinks at reduced prices in the UZH cafeterias Lunch-Check-card with UZH contribution

Healthcare

Special conditions on the Academic Sports Association ASVZ Free seasonal flu vaccinations Rest and relaxation at the quiet room in the university tower

Discounts

Private traffic: Carsharing, rent a vehicle, parking space Digitalization: Hardware, software, mobile phone subscriptions Special conditions on hotel reservations

Conditions of Employment

Policies of the UZH Most UZH staff are employed according to public law

International Services

Support for people from outside Switzerland

Campuses

Campuses Zurich City, Zurich Irchel, Oerlikon and Schlieren Sites Zurich West, Old Botanical Garden, Botanical Garden and Lengg

Location

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Department of Molecular Mechanisms of Disease

Winterthurerstrasse 190, 8057 Zurich, Switzerland

Further information

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Questions about the job

Michael O. Hottiger

Head of Institute
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Questions about the application procedure

Etelka Szabo Sumithram

Secretary

Working at UZH

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The University of Zurich, Switzerland's largest university, offers a range of attractive positions in various subject areas and professional fields. With around 10,000 employees and currently 12 professional apprenticeship streams the University offers an inspiring working environment on cutting-edge research and top-class education. Put your talent and skills to work with us. Find out more about UZH as an employer!