Job Description

Your tasks

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Apply time-resolved cryo-EM and complementary biophysical techniques to capture dynamic structural changes during protein activation with high spatial and temporal resolution Prepare samples of protein complexes for structural and biophysical studies Perform cryo-EM data collection, image processing, and 3D reconstruction Integrate cryo-EM results with additional biophysical data to obtain comprehensive mechanistic insights Present research findings at national and international scientific conferences Publish results in peer-reviewed scientific journals

Your profile

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Master's degree in biochemistry, structural biology or a related discipline completed before February 2026 Experience in one or more of the following: membrane protein biochemistry/biophysics, cryo-EM, X-ray crystallography or spectroscopy Strong motivation to work on ambitious, interdisciplinary projects at the frontier of structural biology

We offer

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Our institution is based on an interdisciplinary, innovative and dynamic collaboration. You will profit from a systematic training on the job, in addition to personal development possibilities and our pronounced vocational training culture. If you wish to optimally combine work and family life or other personal interests, we are able to support you with our modern employment conditions and the on-site infrastructure.

The candidate will be enrolled in the Life Science Zurich Graduate School at the University of Zurich, with a tailored PhD training program and teaching duties, and will also have the opportunity to co-supervise students.

For further information, please contact Dr Polina Isaikina, polina.isaikina@psi.ch.

Please submit your application online by

1 December 2025

(including CV, motivation letter and addresses of referees) for the position as a PhD Student (Index-Nr. 2300-24782).

Paul Scherrer Institute, Human Resources Management, Pascale Bartschi, 5232 Villigen PSI, Switzerland