Job Description

The AO is a medically guided, not-for-profit organization, a global network of surgeons, and the world's leading education, innovation, and research organization specializing in the surgical treatment of trauma and musculoskeletal disorders. We are home to people from all over the world, from different backgrounds, with diverse talents and specialist areas. What binds us together is our passion for excellence, our dedication to our mission of improving patient care, and our understanding that we are stronger together: we are one AO.



The AO Research Institute Davos (ARI) contributes high quality applied preclinical research and development within trauma and disorders of the musculoskeletal system and translation of this knowledge, as well as investigates and improves the performance of surgical procedures, devices, and substances to achieve more effective patient care worldwide. It fosters a close relationship with the AO's medical community, academic societies, and universities and provides a research environment and support for AO clinicians.

Employment type / Anstellungsverhaltnis:

Temporary

Workload percentage / Pensum:

100%

Location / Standort:

Davos Platz, CH

Experience level / gewunschtes Erfahrungsniveau:

Students / Interns

Application language / Bewerbungssprache:

English

Short Description

This PhD position is part of the European Doctoral Network "

SHIELD

" (Strategies for Healing Implant-associated infections and Enhancing Longevity in Devices). Structured around three core scientific pillars--

regenerative medicine

,

biomaterial science

,

and translational research models

--SHIELD supports research on therapeutic strategies, novel antimicrobial materials, and experimental models that bridge laboratory discoveries to clinical applications. The program emphasises interdisciplinary collaboration across

orthopaedics

,

otology

, and

odontology

, integrating basic research with preclinical and clinical studies.

SHIELD

(Strategies for Healing Implant-associated infections and Enhancing Longevity in Devices) is a Marie Sk?odowska-Curie Actions Doctoral Network funded by the European Union's Horizon Europe research and innovation programme under grant agreement No 101226717.



Background information on all DC positions and the SHIELD Doctoral Network is available on:
http://www.shield-dn.eu https://euraxess.ec.europa.eu/jobs/hosting/16-phd-positions-available-highly-motivated-early-career-researchers-be-part-new-msca

Main Responsibilities

DC16: Advanced approaches to understanding biofilm-related infections in orthopaedic implants: from

in vitro

to

in vivo

models

Join the prestigious Marie Sk?odowska-Curie Actions Doctoral Network SHIELD (Strategies for Healing Implant-associated infections and Enhancing Longevity in Devices) and contribute to cutting-edge research aimed at combating implant-associated infections.

Objectives:

This PhD project aims to establish robust in vitro and in vivo models of chronic P. aeruginosa biofilm infections, with a focus on understanding biofilm resilience and evaluating combination therapies. Chronic infections caused by P. aeruginosa pose a significant challenge due to their antibiotic tolerance and immune evasion capabilities. The project will integrate microbiology, molecular biology, imaging, and host-pathogen interaction studies to inform therapeutic development.

Research activities include:

Characterizing mature P. aeruginosa biofilms on titanium and other surfaces:
Quantifying biomass, structure, and metabolic activity Identifying resilient subpopulations and extracellular matrix components Analyzing gene expression of resistance and virulence factors




Investigating synergistic effects of antibiotics and small molecule inhibitors:
Assessing biofilm tolerance to anti-pseudomonal agents Evaluating combination treatments for biofilm prevention and eradication




Developing and validating a zebrafish model for chronic biofilm infections:
Optimizing infection parameters for biofilm formation on implants Using live imaging and immunological assays to monitor infection dynamics Testing treatment strategies and studying immune evasion mechanisms

Training and mobility:

Research secondments at SHIELD partner institutions: + University Hospital Regensburg (Germany)
+ University College Cork (Ireland)
Participation in specialised training workshops and international conferences

Main Requirements

Research Field:
Biological Sciences




Education Level:
Master's degree or bachelor degree




Skills/Qualifications/Specific requirements:
Applicants must hold a Master's degree or equivalent in Microbiology, Biotechnology, clinical sciences or similar providing access to PhD programs and should have experience with experimental research Applicants must have excellent proficiency in written and spoken English Strong motivation and ability to collaborate in an interdisciplinary and international team The appointment will be on a temporary basis for a maximum period of

36 months

(PhD student, regular full-time employment contract). Ideal start date March 2026




Eligibility Criteria:
Have not been awarded a doctoral degree. Researchers who have successfully defended their doctoral thesis but who have not yet formally been awarded the doctoral degree will not be considered eligible Career Stage: Applicants must be within the first four years (full-time equivalent) of their research careers at the date of recruitment. This is measured from the date they obtained the degree that formally entitles them to pursue a doctorate Mobility Rule: Candidates must not have resided or conducted their main activity (work, studies, etc.) in the host organization's country for more than 12 months within the three years immediately preceding their recruitment Nationality: Researchers from any country are eligible, including those from non-European countries

We offer

An interesting and varied job in an exciting and innovative organization The opportunity to be part of a highly committed international team Modern infrastructure High degree of flexibility regarding working hours and location (depending on operational requirements) Generous package of social benefits, including supplementary vacation days and pension scheme contributions Internal skills training opportunities and support for continued education

If you meet the requirements of this challenging opportunity, please submit your application (motivation letter, CV, certificates, reference letters, etc)

Date of publication:

Nov 4, 2025